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blood pool agent
Blood pool agents (BPAs) are a class of magnetic resonance angiography contrast agents.〔(【引用サイトリンク】title=MR Contrast Agents )〕 〔(Blood Pool Agents )〕 Blood pool agents (also known as intravascular contrast agents) are differentiated from other contrast agents due to their high molecular weight and higher relaxivities.〔Geraldes CF, Laurent S, Classification and basic properties of contrast agents for magnetic resonance imaging, Contrast Media Mol Imaging, 2009;4:1-23.〕 Their large size prevents diffusion through the vascular epithelium and leakage into the interstitial space, and because of this they stay in the vascular system for a longer time period. Most contrast agents, leave the vascular system within a few minutes, however blood pool agents remain in the circulation for up to an hour, extending the window available for imaging. Longer image acquisition times allow better signal-to-noise ratio and improved image resolution.
== Roles of blood pool agents ==
Due to their extended time in the circulatory system, blood pool agents can be used for delayed steady-state imaging, and additionally these results can be combined with first pass arterial imaging.〔〔 Their extended circulation time means that they are able to be used for both arterial and venous mapping. Additional uses include: detection of gastrointestinal bleeding; visualization of the vasculature associated with certain tumors; measuring tissue blood volume and perfusion; and detection of endovascular leaks (such as following stent-graft repair of an aortic aneurysm).
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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